Which clause in the Constitution establishes the Constitution as the supreme law?

The Supremacy Clause is found in Article VI, Section 2 of the U.S. Constitution, and it clearly establishes that the Constitution, along with federal laws made pursuant to it, is the supreme law of the land. This clause ensures that state laws cannot conflict with federal laws and reinforces the principle that when there is a conflict between state and federal legislation, federal law prevails. The intention behind this provision was to create a strong federal government that can maintain consistency and cohesiveness in governance across the states, thereby avoiding potential legal chaos that could arise from differing state laws.

Other clauses mentioned have different functions: the Establishment Clause deals with the prohibition of establishing a state religion, the Commerce Clause provides Congress with the power to regulate trade among states, and the Necessary and Proper Clause gives Congress the authority to create laws required to carry out its enumerated powers. Each of these plays a crucial role in the functioning of government but does not establish the supremacy of the Constitution itself.